High-Protein Pizza Breakfast Casserole

Featured in: Breakfast Classics

This satisfying morning casserole combines a unique Greek yogurt dough base with fluffy scrambled eggs, turkey pepperoni, and a blend of mozzarella and cheddar cheeses. The crust comes together quickly using just flour, baking powder, and yogurt, creating a sturdy foundation for the egg and cheese toppings. Perfect for meal prep weekends or feeding a hungry family, this dish bakes up golden and bubbly in under 30 minutes. Each serving delivers 22 grams of protein while keeping carbs moderate, making it an ideal choice for those tracking macros or seeking a filling start to their day.

Updated on Mon, 09 Feb 2026 22:16:54 GMT
Freshly baked High-Protein Pizza Breakfast Casserole with golden melted mozzarella and turkey pepperoni on a spatula, served hot. Save
Freshly baked High-Protein Pizza Breakfast Casserole with golden melted mozzarella and turkey pepperoni on a spatula, served hot. | butterhearth.com

Start your morning with a savory, high-protein meal that combines the best of breakfast and pizza. This High-Protein Pizza Breakfast Casserole features a simple Greek yogurt dough base topped with fluffy eggs, lean turkey pepperoni, and a blend of melty cheeses. It is an easy-to-make dish that is perfect for meal prep or feeding a crowd during a weekend brunch.

Freshly baked High-Protein Pizza Breakfast Casserole with golden melted mozzarella and turkey pepperoni on a spatula, served hot. Save
Freshly baked High-Protein Pizza Breakfast Casserole with golden melted mozzarella and turkey pepperoni on a spatula, served hot. | butterhearth.com

By utilizing a yogurt-based dough, you gain added nutrition and a satisfyingly chewy texture that pairs beautifully with the savory egg custard and classic pizza toppings. This recipe offers a balanced profile of 260 calories and 10 grams of fat per serving, making it a wholesome alternative to traditional breakfast pizzas.

Ingredients

  • Greek Yogurt Dough: 1 ½ cups (180 g) all-purpose flour, 2 teaspoons baking powder, ½ teaspoon salt, 1 cup (240 g) plain Greek yogurt (nonfat or 2%).
  • Egg Mixture: 8 large eggs, ½ cup (120 ml) low-fat milk, ½ teaspoon dried oregano, ½ teaspoon garlic powder, ¼ teaspoon black pepper.
  • Toppings: 1 cup (100 g) shredded part-skim mozzarella cheese, ½ cup (50 g) shredded reduced-fat cheddar cheese, ½ cup (60 g) turkey pepperoni slices.
  • Optional Garnish: 2 tablespoons chopped fresh parsley.
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Instructions

Step 1: Prep
Preheat your oven to 375°F (190°C). Lightly grease a 9x13-inch (23x33 cm) sheet pan or casserole dish.
Step 2: Make the Dough
In a medium bowl, whisk together the flour, baking powder, and salt. Add the Greek yogurt and mix with a spoon until a shaggy dough forms. Knead briefly until smooth.
Step 3: Shape the Base
Press the dough evenly into the prepared pan, forming a thin base.
Step 4: Prepare the Eggs
In a large bowl, whisk together the eggs, milk, oregano, garlic powder, and black pepper until well combined.
Step 5: Assemble
Pour the egg mixture evenly over the dough base. Sprinkle both cheeses over the eggs and top with turkey pepperoni slices.
Step 6: Bake
Bake for 20–25 minutes, or until the eggs are set and the cheese is golden and bubbly. Let cool for 5 minutes, garnish with fresh parsley if desired, then slice and serve.

Zusatztipps für die Zubereitung

When preparing the Greek yogurt dough, be careful not to overwork it; kneading just until smooth ensures a tender crust. To ensure even cooking of the eggs, make sure the dough is pressed into a thin, consistent layer across the bottom of the 9x13-inch pan.

Varianten und Anpassungen

For extra nutrition and flavor, consider adding diced bell peppers, mushrooms, or fresh spinach to the egg mixture. If you prefer a different protein, you can substitute the turkey pepperoni with cooked chicken sausage or vegetarian pepperoni slices.

Serviervorschläge

Serve this casserole warm, optionally with a side of marinara sauce for dipping to enhance the pizza experience. It also pairs well with a fresh fruit salad or a light green side salad for a complete brunch spread.

Sliced High-Protein Pizza Breakfast Casserole reveals fluffy baked eggs and a firm yogurt crust on a white plate. Save
Sliced High-Protein Pizza Breakfast Casserole reveals fluffy baked eggs and a firm yogurt crust on a white plate. | butterhearth.com

Enjoy this nutritious and flavorful breakfast that delivers a satisfying 22g of protein per slice. It is a fantastic way to enjoy the classic flavors of a pizza while maintaining a balanced diet.

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Recipe Questions

Can I make this dish ahead of time?

Yes, you can assemble the entire casserole the night before and refrigerate it unbaked. When ready to serve, bake for an additional 5-10 minutes to account for the cold ingredients. Leftovers also reheat beautifully in the microwave for quick weekday breakfasts.

What can I substitute for Greek yogurt in the dough?

Sour cream or a thick dairy-free yogurt alternative can work as substitutes. Keep in mind the texture may vary slightly, and you might need to adjust the flour quantity to achieve the right dough consistency.

Is this casserole freezer-friendly?

Absolutely! Once baked and cooled, cut into portions and freeze in airtight containers for up to 3 months. Thaw overnight in the refrigerator and reheat in the oven at 350°F until warmed through.

Can I use different meats?

Feel free to swap turkey pepperoni for cooked bacon crumbles, diced ham, or cooked sausage. Just ensure any raw meat is pre-cooked before adding to the casserole to ensure proper food safety.

Why use Greek yogurt in the crust?

Greek yogurt creates a tender, pliable dough that's higher in protein than traditional flour-based crusts. Its acidity activates the baking powder for better rise, while the moisture content eliminates the need for added fats or oils.

How do I know when it's done baking?

The casserole is ready when the eggs are completely set with no jiggly center, the cheese is golden and bubbly, and a knife inserted near the center comes out clean. The edges should be lightly golden brown.

High-Protein Pizza Breakfast Casserole

A protein-rich morning bake with Greek yogurt crust, eggs, pepperoni, and cheese.

Prep duration
20 min
Time to cook
25 min
Complete duration
45 min
Created by Grace Mitchell


Skill Level Easy

Heritage American

Output 6 Portions

Dietary considerations None specified

Components

Greek Yogurt Dough

01 1½ cups all-purpose flour
02 2 teaspoons baking powder
03 ½ teaspoon salt
04 1 cup plain Greek yogurt, nonfat or 2%

Toppings

01 8 large eggs
02 ½ cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 ½ cup shredded reduced-fat cheddar cheese
05 ½ cup turkey pepperoni slices
06 ½ teaspoon dried oregano
07 ½ teaspoon garlic powder
08 ¼ teaspoon black pepper
09 2 tablespoons fresh parsley, chopped

Directions

Stage 01

Prepare Baking Pan: Preheat oven to 375°F. Lightly grease a 9x13-inch sheet pan or casserole dish with cooking spray or butter.

Stage 02

Mix Dough Base: In a medium bowl, whisk together flour, baking powder, and salt. Add Greek yogurt and mix with a spoon until shaggy dough forms. Knead briefly until smooth.

Stage 03

Form Base Layer: Press dough evenly into prepared pan, forming a thin, uniform base layer covering the entire surface.

Stage 04

Prepare Egg Mixture: In a large bowl, whisk together eggs, milk, oregano, garlic powder, and black pepper until fully combined and well incorporated.

Stage 05

Add Egg Layer: Pour egg mixture evenly over dough base, distributing it across the entire surface.

Stage 06

Top with Cheese and Pepperoni: Sprinkle mozzarella and cheddar cheese evenly over eggs. Top with turkey pepperoni slices distributed across the casserole.

Stage 07

Bake Casserole: Bake for 20-25 minutes, or until eggs are completely set and cheese is golden and bubbly on top.

Stage 08

Cool and Serve: Remove from oven and let cool for 5 minutes. Garnish with fresh parsley if desired. Slice into portions and serve warm.

Necessary tools

  • 9x13-inch sheet pan or casserole dish
  • Mixing bowls
  • Whisk
  • Measuring cups and spoons
  • Knife and cutting board

Allergy details

Review each component for potential allergens and consider consulting with a healthcare provider if you're unsure about certain ingredients.
  • Contains wheat and gluten
  • Contains eggs
  • Contains milk and dairy
  • Check turkey pepperoni and cheese labels for additional allergens

Nutritional information (per portion)

These values are estimates only and shouldn't replace professional medical guidance.
  • Energy Value: 260
  • Fats: 10 g
  • Carbohydrates: 19 g
  • Protein Content: 22 g